AI Startup Jobs in San Diego
There are currently 107 AI startup jobs in San Diego from 20 companies. Top hiring companies include Shield AI, Firestorm Labs, Debut. Defense & Aerospace roles make up the largest share of open positions.
20 of the 20 companies hiring in San Diego (100%) have verified funding data — most commonly Series B (5), Series C (4), Series D (4). Source: Fast AI Jobs company dataset, September 2026.
Top Hiring Companies
Shield AI
Defense AI company building autonomous aircraft and AI pilot technology for military applications.
Firestorm Labs
Builds containerized, forward-deployable drone manufacturing units that can 3D-print unmanned aerial systems in under 24 hours at or near the front line.
Debut
Debut is a beauty biotechnology company that uses AI-powered ingredient discovery and biofermentation to create high-performing, sustainable beauty ingredients from molecules that nature produces only in minute quantities. Named one of TIME100 Most Innovative Companies in 2025, the company partners with major brands like L'Oreal to develop next-generation skincare actives with a focus on skin longevity. Headquartered in San Diego, Debut has raised over $89 million and screens billions of candidate molecules through its proprietary platform.
Sprinter Health
Mobile diagnostics + virtual care, providing modern at-home healthcare.
Headlight
Headlight is a mental health company dedicated to transforming the way mental health services are delivered with a clinician-centered model, innovative technology, and a commitment to accessibility and affordability for patients both in-person and virtually.
Netradyne
AI-powered fleet safety and driver analytics.
LangChain
LangChain provides open-source frameworks and a managed platform (LangSmith, LangGraph) for building, observing, and deploying LLM-powered applications and agents. Its composable, modular components let developers integrate large language models into production workflows. Backed by Sequoia and IVP, LangChain is the leading developer framework for agentic AI.
Clear Street
Clear Street is a cloud-native clearing, custody, and brokerage platform built to modernize capital markets infrastructure. It serves institutional clients including hedge funds, family offices, and ETF issuers across equities, options, futures, and fixed income.
Recent Job Listings
FAQ
How many AI startup jobs are available in San Diego?
There are currently 107 AI startup jobs in San Diego from 20 companies on Fast AI Startup Jobs.
How many of the companies hiring in San Diego are funded?
20 of the 20 companies hiring in San Diego (100%) have verified funding data, most commonly Series B (5 companies), Series C (4 companies), Series D (4 companies). Funding stage and amount are tracked for roughly 97% of all companies in the Fast AI Jobs dataset.
Which companies are hiring the most in San Diego?
The top hiring companies in San Diego include Shield AI, Firestorm Labs, Debut. Visit each company profile for detailed job listings and company information.
What types of roles are most common in San Diego?
Defense & Aerospace roles make up the largest share of AI startup jobs in San Diego. Other common categories include engineering, research, product, and operations roles.
How often are these job listings updated?
Job listings are refreshed daily from official company career pages and public job boards. All links point directly to original application pages.
Where do the job links go?
Job links point to official company career pages or public job listings, not re-hosted application forms.